Supraja Varadarajan

Image of the Month

Nestin fibers transport netrin1 expressed in the floor plate to the axons crossing the commissure. Mouse embryonic spinal cord labeled with Sox2 (red), axons labeled with neurofilament (blue).

By: Supraja Varadarajan – Samantha Butler Laboratory


The Neuroscience Interdepartmental Program


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Upcoming Events

Joint Seminars in Neuroscience Lecture Series

Tuesday, January 9th, 2018
12:00pm - 1:00pm
Neuroscience Research Building (NRB) 1st Floor Auditorium

Debra Silver, Ph.D.
Departments of Molecular Genetics and Microbiology, Neurobiology and Cell Biology
Duke University School of Medicine, Durham, North Carolina

"Dynamic Post-Transcriptional Control of Cortical Development and Disease"


Our lab investigates genetic and cellular mechanisms controlling cerebral cortex development, and contributing to neurodevelopmental pathologies and brain evolution. We study neural progenitors, essential cells which generate neurons at the root of brain development. We employ mouse genetics, iPSCs, live imaging, and genomics. We use these multidisciplinary approaches to investigate genetic changes that underlie human-specific brain development. A major focus of our research is on post-transcriptional regulation during cortical development. We study RNA binding proteins that control cell fate in the developing brain and are implicated in neurodevelopmental disease. Our group has also discovered that mRNA is rapidly transported in neural stem cells where it can be locally translated in distal compartments. This talk will largely focus on our ongoing studies to investigate these layers of RNA regulation within embryonic neural stem cell populations.







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